Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A universal nitric oxide delivery system

J D Young1

  • 1Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford.

British Journal of Anaesthesia
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The natural history of epiphora in childhood.

Eye (London, England)·1998
Same author

Effect of L-lysine on nitric oxide production in ovine endotoxaemia.

British journal of anaesthesia·1998
Same author

Demonstration of equilibrative nucleoside transporters (hENT1 and hENT2) in nuclear envelopes of cultured human choriocarcinoma (BeWo) cells by functional reconstitution in proteoliposomes.

The Journal of biological chemistry·1998
Same author

Conductimetry for enzyme teaching.

Biochemical Society transactions·1998
Same author

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

Cancer research·1998
Same author

Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs.

The Journal of biological chemistry·1998

A new nitric oxide delivery system for adult ventilators maintains a consistent 16 vpm concentration. Laboratory tests confirm its stability across various breathing volumes and rates.

Area of Science:

  • Medical Devices
  • Respiratory Therapy
  • Biomedical Engineering

Background:

  • Nitric oxide (NO) is a vasodilator used therapeutically in respiratory conditions.
  • Accurate and stable delivery of inhaled NO is crucial for patient safety and treatment efficacy.
  • Existing delivery systems may struggle to maintain consistent NO concentrations with varying ventilator settings.

Purpose of the Study:

  • To develop and evaluate a novel nitric oxide delivery system for adult mechanical ventilation.
  • To ensure a constant inspired nitric oxide concentration despite fluctuations in ventilation parameters.
  • To assess the system's performance under a range of clinically relevant tidal volumes, respiratory rates, and flow profiles.

Main Methods:

  • Development of a specialized nitric oxide delivery system integrated with adult ventilators.

Related Experiment Videos

  • Laboratory testing using a breathing simulator to mimic physiological conditions.
  • Administration of tracer gas concentrations equivalent to nitric oxide at a target of 16 volumes per million (vpm).
  • Evaluation of system performance across diverse tidal volumes (500-900 ml), respiratory rates (10-20 b.p.m.), and inspiratory flow profiles (square, sine, decelerating ramp).

    • Main Results:

    • The developed system successfully maintained inspired nitric oxide concentrations within a narrow range (13.8-18 vpm).
    • Consistent performance was observed across all tested tidal volumes, respiratory rates, and flow profiles.
    • The system demonstrated robust stability, compensating for variations in minute and tidal volumes.

    Conclusions:

    • The novel nitric oxide delivery system effectively provides a stable and precise concentration of inhaled nitric oxide for adult mechanical ventilation.
    • This system offers a reliable solution for therapeutic NO administration, adaptable to diverse patient ventilation needs.
    • Further clinical validation is warranted to confirm its efficacy and safety in patient populations.