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Related Experiment Videos

Nitrosoureas in multiple myeloma

S E Salmon

    Cancer Treatment Reports
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Carmustine (BCNU) and other nitrosoureas show effectiveness in multiple myeloma remission induction and maintenance. These agents are valuable for patients relapsing after initial alkylating-agent therapy.

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    Area of Science:

    • Oncology
    • Hematology
    • Pharmacology

    Background:

    • Multiple myeloma treatment often involves combination chemotherapy.
    • Nitrosoureas, including carmustine (BCNU) and lomustine (CCNU), are established agents in myeloma therapy.

    Purpose of the Study:

    • To evaluate the efficacy of BCNU and related nitrosoureas in multiple myeloma.
    • To assess the role of nitrosoureas in remission induction, maintenance, and relapse settings.

    Main Methods:

    • Review of cooperative-group and single-institution studies.
    • Analysis of BCNU and CCNU in combination with prednisone, melphalan, and cyclophosphamide.
    • Evaluation of nitrosoureas in relapsed and refractory multiple myeloma.

    Main Results:

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    • BCNU with prednisone, or in combination regimens, is effective for remission induction in previously untreated multiple myeloma.
    • Results with BCNU are comparable to other agents for remission induction, duration, and survival.
    • BCNU plus prednisone shows similar efficacy to melphalan plus prednisone for remission maintenance.
    • Nitrosoureas are effective for relapsing patients, with encouraging results from pilot studies using BCNU and adriamycin.

    Conclusions:

    • BCNU and CCNU are valuable agents in multiple myeloma, particularly for remission induction and maintenance.
    • Nitrosoureas play a significant role in managing relapsed multiple myeloma.
    • Ongoing investigations explore novel combinations involving nitrosoureas for relapsed disease.