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Human apo A-I in transgenic mice is more efficient in activating lecithin:cholesterol acyltransferase than mouse apo
E Golder-Novoselsky1, A V Nichols, E M Rubin
1Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Biochimica Et Biophysica Acta
|January 20, 1995
Abstract:
This study shows that, in control and transgenic mice, there is a parallel increase in LCAT activity and plasma apo A-I concentrations during postnatal development. We also demonstrate that human apo A-I is a much more efficient activator (1.6-fold) of mouse LCAT activity than mouse apo A-I. We propose that the differences in amino acid sequence between human and mouse apo A-I may account for the higher LCAT activity with human apo A-I.
