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Related Experiment Videos

Fetal therapy

K Nicolaides1, H Pettersen

  • 1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London UK.

Current Opinion in Obstetrics & Gynecology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Twin to twin transfusion syndrome and twin reversed arterial perfusion sequence impact many identical twin pregnancies, risking fetal death. Intrauterine treatment improves survival rates for at least one twin in affected pregnancies.

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Area of Science:

  • Perinatology
  • Maternal-Fetal Medicine
  • Reproductive Genetics

Background:

  • Twin to twin transfusion syndrome (TTTS) and twin reversed arterial perfusion (TRAP) sequence affect up to 15% of monozygotic twin pregnancies.
  • These conditions can result in miscarriage, extremely premature delivery, and fetal demise.
  • Early identification and intervention are crucial for improving outcomes.

Purpose of the Study:

  • To evaluate the efficacy of intrauterine treatment for TTTS and TRAP sequence.
  • To assess the impact of treatment on the survival rates of twins in affected pregnancies.
  • To highlight advancements in managing complex monochorionic twin complications.

Main Methods:

  • Review of intrauterine treatment modalities for TTTS and TRAP sequence.

Related Experiment Videos

  • Analysis of survival rates in treated versus untreated twin pregnancies.
  • Comparison of outcomes including gestational age at delivery and neonatal survival.

    • Main Results:

    • Intrauterine treatment demonstrates a significant increase in the survival rate of at least one twin.
    • Treatment protocols have led to improved perinatal outcomes in complicated twin gestations.
    • Reduced rates of miscarriage and very premature delivery observed post-intervention.

    Conclusions:

    • Intrauterine treatment is an effective strategy for managing twin to twin transfusion syndrome and twin reversed arterial perfusion sequence.
    • Current therapeutic approaches enhance the likelihood of survival for one or both twins.
    • Continued research and refinement of treatment methods are vital for optimizing outcomes in high-risk twin pregnancies.