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Related Experiment Videos

Double-pulse defibrillation using pulse separation based on the fibrillation cycle length

R J Sweeney1, R M Gill, P R Reid

  • 1Department of Electrophysiology Research, Lilly Research Laboratory Division, Eli Lilly and Company, Indianapolis, Indiana.

Journal of Cardiovascular Electrophysiology
|September 1, 1994
PubMed
Summary

This study explored double-pulse (DP) defibrillation shocks timed to the fibrillation cycle length (FCL). Optimized DP shocks achieve defibrillation with equivalent energy to single shocks, reducing current.

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Area of Science:

  • Cardiovascular Research
  • Medical Devices
  • Electrophysiology

Background:

  • Investigated a novel defibrillation method using two shocks delivered sequentially to the same electrodes.
  • The timing of these double-pulse (DP) shocks was based on the fibrillation cycle length (FCL).

Purpose of the Study:

  • To determine the optimal separation for DP shocks based on FCL for effective defibrillation.
  • To compare the energy requirements and success rates of DP shocks versus single shocks.

Main Methods:

  • Used a computerized system in anesthetized dogs to determine FCL and deliver DP shocks.
  • Varied DP shock separations relative to FCL and administered drugs to alter FCL.
  • Measured energy for 50% defibrillation success (E50) across different configurations and conditions.

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Main Results:

  • Optimal DP shock separation was found to be approximately 85% of the FCL.
  • DP shocks with optimal separation used the same total energy as single shocks in single-pathway configurations.
  • DP shocks required approximately 20% more energy in three-electrode configurations compared to single shocks.

Conclusions:

  • DP defibrillation with 85% FCL separation is effective in single-pathway configurations, matching single-shock energy.
  • This method doubles shock duration, reducing peak currents by 20-30% without increasing total energy.
  • Optimizing DP shock timing offers a potential strategy for improved defibrillation efficacy and safety.