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A structure activity relationship study on 1-isopropylamino-3-(2'-substituted naphthoxy)-propan-2-ois analogs
A K Srivastava1, N Mishra, A A Khan
1Department of Chemistry, University of Allahabad, India.
Research Communications in Molecular Pathology and Pharmacology
|September 1, 1994
Abstract:
The structure activity relationship of 1-isopropylamino-3-(2'-substituted naphthoxy) propan-2-ois analogs, which are beta-adrenergic blocking drugs, is discussed. The blocking activity of these compounds is found to be dominantly controlled by electronic and steric factors. Significant correlations have been obtained between the blocking activity and negentropy, equalized eletronegativity and partial charge.