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Related Experiment Videos

Systemic responses in patients with intermittent claudication after treadmill exercise

A T Edwards1, A D Blann, V J Suarez-Mendez

  • 1University Department of Surgery, University Hospital of South Manchester, UK.

The British Journal of Surgery
|December 1, 1994
PubMed
Summary

Treadmill exercise increases neutrophils and thromboxane in claudicant patients, indicating endothelial injury. Reduced antioxidant activity in these patients may worsen free radical damage.

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Biochemistry

Background:

  • Peripheral artery disease, characterized by claudication, involves impaired blood flow and endothelial dysfunction.
  • Exercise is a key intervention, but its acute effects on markers of inflammation and endothelial injury in claudicant patients require further elucidation.

Purpose of the Study:

  • To investigate the acute effects of short-duration treadmill exercise on systemic neutrophil count, plasma thromboxane, and von Willebrand's factor in patients with claudication compared to healthy controls.
  • To assess the role of antioxidant capacity, specifically glutathione peroxidase and selenium levels, in claudicant patients and their response to exercise.

Main Methods:

  • A 5-minute treadmill exercise test was performed on patients with claudication and healthy controls.

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  • Measurements included systemic neutrophil count, plasma thromboxane levels, serum von Willebrand's factor, plasma glutathione peroxidase activity, and plasma selenium concentrations before and at various time points after exercise.

    • Main Results:

    • Claudicant patients exhibited higher resting neutrophil counts and significantly greater increases in neutrophils and plasma thromboxane post-exercise compared to controls.
    • Elevated resting von Willebrand's factor (vWF) in claudicants persisted post-exercise, with a further increase observed 60 minutes after exercise.
    • Claudicant patients showed lower plasma glutathione peroxidase activity and selenium concentrations, suggesting reduced antioxidant capacity.

    Conclusions:

    • Short-term treadmill exercise induces neutrophilia and thromboxane production in claudicant patients, correlating with endothelial injury markers like vWF.
    • Reduced antioxidant capacity, indicated by lower glutathione peroxidase and selenium levels, may exacerbate exercise-induced endothelial damage in claudication by allowing unopposed free radical action.