Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An Excel spreadsheet computer program combining algorithms for prediction of protein structural characteristics

J Clotet1, J Cedano, E Querol

  • 1Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra, Spain.

Computer Applications in the Biosciences : CABIOS
|September 1, 1994
PubMed
Summary

This study introduces a user-friendly computer program for predicting protein structural characteristics using the Chou and Fasman algorithm. It aids researchers in analyzing secondary structures, helix caps, and cysteine states.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender perspective in the implementation of hygiene in cardiology intensive care.

Enfermeria intensiva·2024
Same author

Split-thickness skin grafts obtained from adjacent hairy skin for reconstructing auricular concave surfaces after Mohs surgery.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer.

Scientific reports·2017
Same author

Assessment of EGF receptor ligand expression in gastric carcinoma and in lesional skin of paraneoplastic acanthosis nigricans: a case report.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

Does syncope require rhythmic and non-rhythmic evaluation in patients with previous MI?

Heart Asia·2016
Same author

A dynamic model of the proteins that form the initial iron-sulfur cluster biogenesis machinery in yeast mitochondria.

The protein journal·2013

Area of Science:

  • Computational Biology
  • Structural Bioinformatics
  • Protein Science

Background:

  • Accurate prediction of protein structural characteristics is crucial for understanding protein function.
  • Existing methods often require specialized expertise or complex computational resources.

Purpose of the Study:

  • To develop and report a versatile computer program for predicting various protein structural features.
  • To provide researchers with an accessible tool for protein structure analysis on personal computers.

Main Methods:

  • Implementation of the modified Chou and Fasman algorithm for secondary structure prediction.
  • Integration of complementary analyses including N-cap and C-cap rules, structural class prediction, and motif searching.
  • Inclusion of algorithms for domain boundary and loop prediction, cysteine state determination, hydropathy profiling, and flexibility plotting.

Related Experiment Videos

Main Results:

  • The program successfully integrates multiple algorithms for comprehensive protein structure prediction.
  • It offers a decision-support system for secondary structure prediction through complementary analyses.
  • Various established methods for hydropathy and flexibility analysis are incorporated.

Conclusions:

  • The developed program offers a valuable and accessible tool for predicting diverse protein structural characteristics.
  • It enhances the decision-making process for researchers in structural bioinformatics.
  • The software facilitates a more integrated approach to protein structure analysis.