Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do patients with primary pulmonary hypertension develop extensive central thrombi?

K M Moser1, P F Fedullo, W E Finkbeiner

  • 1Department of Medicine, University of California, San Diego, School of Medicine 92103.

Circulation
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Distribution of bluetongue in the United States of America, 1991-2002.

Veterinaria italiana·2010
Same author

Bluetongue surveillance methods in the United States of America.

Veterinaria italiana·2010
Same author

Computer processing of spectrograms for absolute intensities.

Applied optics·2010
Same author

The nature and role of metabolic leakage from root-knot nematode galls and infection by Rhizoctonia solani.

Journal of nematology·2009
Same journal

A Bundle to Frame Guidelines and American Heart Association Statements.

Circulation·2026
Same journal

<i>Circulation</i> Editors and Editorial Board.

Circulation·2026
Same journal

A New <i>Circulation</i>, For You.

Circulation·2026
Same journal

Cardiovascular Risk Reduction With GLP-1 RA Drugs.

Circulation·2026
Same journal

Obesity, Severe Obesity, and Abdominal Obesity in US Youth and Adults From 1999 to 2023.

Circulation·2026
Same journal

Lipid Profile Testing and Interpretation.

Circulation·2026
See all related articles

Large central thrombi can occur in primary pulmonary hypertension, even without significant hemodynamic impact. Perfusion lung scans lacking defects may indicate this condition, necessitating further investigation.

Area of Science:

  • Cardiology
  • Pulmonology
  • Radiology

Background:

  • Differentiating chronic major vessel thromboembolic pulmonary hypertension from primary pulmonary hypertension is crucial due to distinct treatment strategies.
  • Surgical thromboendarterectomy offers a cure for thromboembolic pulmonary hypertension, while primary pulmonary hypertension management includes oxygen, vasodilators, and potentially anticoagulation or lung transplantation.
  • The occurrence of large thrombi in central pulmonary arteries was previously undescribed in primary pulmonary hypertension.

Observation:

  • Three cases of pulmonary hypertension with massive central pulmonary artery thrombi were analyzed.
  • These large central thrombi were found to be hemodynamically insignificant in the described patients.
  • Perfusion lung scans did not reveal segmental or larger defects in any of the patients.

Related Experiment Videos

Findings:

  • Large central thrombi can develop in patients diagnosed with primary pulmonary hypertension.
  • The absence of segmental or larger defects on perfusion lung scans should raise suspicion for this condition.
  • Standard imaging like chest computed tomography may not adequately distinguish these thrombi from operable chronic major vessel thromboembolic hypertension.

Implications:

  • Accurate diagnosis requires careful review of lobar/segmental artery findings, pulmonary angiogram, angioscopy, and cardiac catheterization data to assess hemodynamic significance.
  • These findings suggest a potential role for anticoagulant therapy in managing primary pulmonary hypertension.
  • Distinguishing between these conditions is essential for appropriate patient management and treatment selection.