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Antianxiety actions of Ca2+ channel antagonists with Vogel-type conflict test in rats
Y Matsumoto1, Y Kataoka, Y Watanabe
1Department of Pharmacology, School Nurse Training, Kyushu Women's Jr. College, Japan.
European Journal of Pharmacology
|October 13, 1994
Abstract:
We examined the effects of various derivatives of Ca2+ channel antagonists in a modified rat Vogel-type conflict model. Flunarizine (10 and 20 mg/kg), nicardipine (20 mg/kg), and verapamil (20 mg/kg), given as single i.p. injections, significantly increased punished lickings by 50-110%. Chronic administration of diltiazem, at 20 mg/kg i.p. for 8 days, a dose ineffective with a single i.p. injection, produced a significant anticonflict action. The possibility that Ca2+ channel antagonists have anxiolytic action should be considered.