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Necrotizing enteritis simulating Pig-Bel disease in northern India
S C Gupta1, V Mishra, S P Mishra
1Department of Pathology, Moti Lal Nehru Medical College, Allahabad.
Summary
A clinicopathological study identified a necrotizing enteritis in India, distinct from Pig-Bel disease. This condition predominantly affects young adult vegetarians and exhibits significant seasonal variation.
Area of Science:
- Gastroenterology
- Pathology
- Epidemiology
Background:
- Necrotizing enteritis, a severe intestinal condition, shares similarities with Pig-Bel disease found in Papua New Guinea.
- Understanding the clinicopathological features of such diseases is crucial for accurate diagnosis and management.
Purpose of the Study:
- To conduct a clinicopathological study of patients presenting with symptoms mimicking Pig-Bel disease.
- To characterize the clinical presentation, pathological findings, and epidemiological factors of this condition in India.
Main Methods:
- A retrospective clinicopathological analysis of 95 patients over ten years.
- Patients presented with acute abdominal pain, diarrhea, rectal bleeding, and vomiting.
- Inclusion criteria required lesions similar to those seen in Pig-Bel disease.
Main Results:
- The majority (89%) of affected patients were young adult vegetarians from lower socio-economic backgrounds.
- A strong seasonal pattern was observed, with 94% of cases occurring between May and August.
- The jejunum was the most frequently involved site (95%), exhibiting characteristic 'skip' lesions with gangrene and perforation. Histological examination revealed marked necrosis and congestion.
Conclusions:
- A disease entity similar to Pig-Bel disease exists in India.
- This condition disproportionately affects young adult vegetarians.
- The etiology may differ from that of Pig-Bel disease in endemic regions, warranting further investigation.