Related Experiment Videos
An outbreak of multidrug resistant Salmonella typhimurium in Delhi (India)
Abstract:
A total of 85 patients with multidrug resistant S. typhimurium were isolated between May and September 1991 at the Sir Ganga Ram Hospital, New Delhi, India. Fifty eight (72.5%) patients out of 80 stool culture positives suffered from enteritis and 23 (39.6%) of them settled with oral rehydration therapy alone. All strains were sensitive to 4 aminoquinolones (oflaxcin) but five were resistant to third generation cephalosporin (Cefotaxime; MIC between 50-75 micrograms/ml) whereas 88-96 per cent isolated were resistant to most of the other antibiotics. The convalescent carrier rate was prolonged with the use of antibiotics. The phage type of S. typhimurium isolated from the index and other cases was 178 and multidrug resistance strains had seven plasmids (1.2 to 16 kb). Barrier nursing and sodium hypochlorite disinfection helped in limiting the outbreak.
Insights
Multidrug-resistant Salmonella typhimurium outbreaks require effective control. Oral rehydration therapy alone treated most enteritis cases, while barrier nursing and disinfection limited spread.
Area of Science:
- Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Multidrug-resistant Salmonella typhimurium (S. typhimurium) poses a significant public health threat.
- Antibiotic resistance in bacterial pathogens is a growing global concern.
Purpose of the Study:
- To investigate an outbreak of multidrug-resistant S. typhimurium.
- To identify effective treatment and control strategies for S. typhimurium infections.
Main Methods:
- Retrospective analysis of patient data from May to September 1991.
- Antimicrobial susceptibility testing of S. typhimurium isolates.
- Plasmid profiling and phage typing of S. typhimurium strains.
Main Results:
- Eighty-five patients with multidrug-resistant S. typhimurium were identified.
- Of 80 stool culture positives, 58 patients (72.5%) had enteritis, with 23 (39.6%) successfully treated with oral rehydration therapy alone.
- All isolates were sensitive to ofloxacin, but five were resistant to cefotaxime. 88-96% were resistant to other antibiotics.
- Antibiotic use prolonged convalescent carrier rates.
- The predominant phage type was 178, and resistant strains harbored seven plasmids.
- Barrier nursing and sodium hypochlorite disinfection were effective in limiting the outbreak.
Conclusions:
- Oral rehydration therapy is effective for S. typhimurium enteritis.
- Multidrug-resistant S. typhimurium outbreaks can be controlled using barrier nursing and disinfection.
- Prudent antibiotic use is crucial to prevent prolonged carrier states.