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Related Experiment Videos

Short term methotrexate therapy in psoriasis

B Kumar1, S Handa, I Kaur

  • 1Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh.

The Indian Journal of Medical Research
|December 1, 1994
PubMed
Summary
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Methotrexate (MTX) effectively treated psoriasis, with 90% of patients achieving drug-free periods. This approach reduced cumulative MTX dosage and the need for repeat liver biopsies in psoriasis management.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Methotrexate (MTX) is a common treatment for severe psoriasis.
  • Managing long-term MTX therapy requires careful monitoring due to potential toxicity.

Purpose of the Study:

  • To review data on methotrexate (MTX) treatment for severe psoriasis.
  • To evaluate the safety and efficacy of a protocol involving rapid MTX withdrawal.
  • To assess the impact of this protocol on cumulative dosage and liver biopsy frequency.

Main Methods:

  • Retrospective review of 82 patients with severe psoriasis treated with weekly oral MTX.
  • MTX dosage ranged from 3.75-30 mg/week based on body weight.
  • Protocol aimed for rapid MTX withdrawal to achieve 4-6 month drug-free periods.

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Main Results:

  • MTX was safely administered, even in 7 patients with contraindications.
  • Up to 90% of patients could have MTX withdrawn within an average of 25 weeks.
  • This strategy reduced total cumulative MTX dose and the need for repeat liver biopsies.

Conclusions:

  • Rapid MTX withdrawal is a feasible strategy for managing severe psoriasis.
  • This approach can lead to significant drug-free intervals.
  • The protocol may mitigate long-term toxicity risks associated with MTX therapy.