Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[A case report: cryptococcal meningitis and fluconazole therapy]

S Takeda1, I Tatara, K Kono

  • 1Second Department of Internal Medicine, Fukuoka University School of Medicine.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiology of nosocomial infections at Fukuoka University Hospital.

Infection control and hospital epidemiology·2000
Same author

[A case of male who was taken systemic lupus erythematosus with chilblain lupus].

Ryumachi. [Rheumatism]·1998
Same author

Prolongation of hamster-to-rat cardiac xenograft survival by hyperimmune blood transfusion without immunosuppression.

Transplantation proceedings·1996
Same author

[Clinical studies of fluconazole in patients with deep-seated fungal infection in intravenous hyperalimentation (IVH)].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1996
Same author

The anticoagulant effect of antithrombin III on hyperacute xenograft rejection.

Transplantation proceedings·1996
Same author

Prolongation of xenograft survival by soluble complement receptor type 1 and antithrombin-III combination therapy.

Transplantation proceedings·1996

This case study shows that fluconazole alone effectively treated cryptococcal meningitis in an immunocompromised patient. This antifungal therapy improved symptoms and cleared the infection, suggesting a potential alternative to standard treatments.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Pharmacology

Background:

  • Systemic lupus erythematosus (SLE) patients on immunosuppressants like azathioprine and prednisolone are at risk for opportunistic infections.
  • Cryptococcal meningitis is a serious central nervous system infection, particularly in immunocompromised individuals.

Observation:

  • An 18-year-old female with SLE presented with headache and vomiting, diagnosed with cryptococcal meningitis.
  • The patient was treated with 400 mg of fluconazole (FLCZ) daily.

Findings:

  • Fluconazole monotherapy led to clinical improvement and decreased cryptococcal antigen levels within one month.
  • Cerebrospinal fluid analysis confirmed sterilization, indicating successful eradication of the fungal infection.
  • The patient's symptoms resolved, demonstrating the efficacy of fluconazole in this case.

Related Experiment Videos

Implications:

  • This case suggests that fluconazole monotherapy may be a viable and effective treatment option for cryptococcal meningitis.
  • It challenges the necessity of standard combination therapy with amphotericin B (AMPH) in select patient populations.
  • Further research into FLCZ monotherapy for cryptococcal meningitis in immunocompromised patients is warranted.