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Related Experiment Videos

Amino acids mediate postprandial jejunal proabsorption

O J Hines1, A J Bilchik, S W Ashley

  • 1Department of Surgery, University of California, Los Angeles.

The Journal of Surgical Research
|January 1, 1995
PubMed
Summary

Amino acid transporters, similar to the sodium-glucose cotransporter, significantly enhance jejunal ion and water absorption after a meal. This suggests amino acids play a crucial role in the body's proabsorptive response.

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Area of Science:

  • Physiology
  • Gastroenterology
  • Molecular Biology

Background:

  • Meal ingestion stimulates small intestinal ion and water transport, a process known as proabsorption.
  • The apical sodium-glucose cotransporter is currently believed to be the primary mediator of this response.
  • Amino acid absorption also largely relies on sodium-dependent, secondary active transport mechanisms.

Purpose of the Study:

  • To investigate the role of amino acid transport in mediating jejunal ion and water absorption following a meal.
  • To compare the effect of amino acid transport on absorption with that of glucose transport.

Main Methods:

  • Exteriorized, neurovascularly intact jejunal loops were created in six female mongrel dogs.
  • Loops were perfused with buffers containing specific amino acids (aspartate, leucine, glycine, lysine) or glucose.

Related Experiment Videos

  • Net water and electrolyte absorption were measured using [14C]polyethylene glycol as a volume marker before and after a mixed meal.

    • Main Results:

    • Aspartic acid, leucine, and glycine significantly potentiated sodium and water absorption post-meal (P < 0.05).
    • The absorptive enhancement by these amino acids was comparable to that observed with 10 mM glucose.
    • Lysine did not show a significant effect on sodium and water absorption.

    Conclusions:

    • Amino acid transporters, analogous to the sodium-glucose cotransporter, are key mediators of meal-induced jejunal sodium and water absorption.
    • Amino acids may contribute significantly to the overall proabsorptive response in the small intestine.
    • This highlights the importance of amino acid transport in regulating intestinal fluid and electrolyte balance.