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[Sugar substitutes in the diabetic diet]
Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Beiheft
|January 1, 1976
Summary
Sugar substitutes like fructose, sorbitol, and xylitol offer better glucose utilization for diabetics than glucose. Proper dosage improves carbohydrate tolerance and metabolic stability, though osmotic diarrhea can occur with high doses of sorbitol and xylitol.
Area of Science:
- Endocrinology
- Metabolic Science
- Nutritional Science
Context:
- Diabetes mellitus is characterized by impaired glucose utilization.
- Sugar substitutes are explored as alternatives to glucose and saccharose.
- Understanding the metabolic effects and side effects of sugar substitutes is crucial for diabetic management.
Purpose:
- To investigate the absorption, utilization, and side-effects of fructose, sorbitol, and xylitol.
- To compare the metabolic impact of these sugar substitutes with glucose and saccharose in healthy and diabetic subjects.
- To evaluate the potential of sugar substitutes in improving carbohydrate tolerance and metabolic stability in diabetes.
Summary:
- Fructose, sorbitol, and xylitol are absorbed more slowly than glucose, leading to better utilization in conditions of limited insulin production.
- These sugar substitutes are metabolized enzymatically, primarily in the liver, with a lesser impact on blood glucose and serum insulin levels compared to glucose.
- While generally safe with correct dosage, high oral intake of sorbitol and xylitol can cause osmotic diarrhea due to slow absorption.
Impact:
- Sugar substitutes can enhance carbohydrate tolerance and stabilize metabolism in diabetic patients when used appropriately.
- Their pronounced antiketogenic activity is beneficial for metabolic control.
- Potential side effects are minimal with correct oral dosage, making them valuable tools in diabetes management, provided caloric intake is considered.