Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy

T Kawanami1, T Kato, J F Llena

  • 1Department of Pathology, Montefiore Medical Center, New York.

Neuroscience Letters
|August 1, 1994
PubMed
Summary

Olivary hypertrophy alters synaptophysin (SYP) patterns in the inferior olivary nucleus. Presynaptic terminals show changes, with more SYP dots on neurons and fewer in the surrounding neuropil.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Spinal intradural arachnoid cyst associated with enlarged filum terminale].

No shinkei geka. Neurological surgery·1995
Same author

[A case of systemic lupus erythematosus associated with cerebral infarction and cerebral hemorrhage].

No to shinkei = Brain and nerve·1995
Same author

[A case of growing up aneurysms with occlusion of basilar artery].

No shinkei geka. Neurological surgery·1995
Same author

Craniofacial deformities associated with juvenile hyperthyroidism.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·1995
Same author

Expression and biological activities of bovine interleukin 4: effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro.

Cellular immunology·1995
Same author

[Combined hormone and chemotherapy for the patients with advanced prostate cancer].

Gan to kagaku ryoho. Cancer & chemotherapy·1995

Area of Science:

  • Neuroscience
  • Cell Biology
  • Immunohistochemistry

Background:

  • The inferior olivary nucleus plays a crucial role in motor control and learning.
  • Olivary hypertrophy is a rare neurological condition characterized by enlargement of the inferior olivary nucleus.
  • Understanding the cellular changes in olivary hypertrophy is essential for elucidating its pathophysiology.

Purpose of the Study:

  • To investigate the distribution and expression of synaptophysin (SYP) in the inferior olivary nucleus in cases of olivary hypertrophy.
  • To determine if SYP, a marker for presynaptic vesicles, is altered in hypertrophied olives compared to controls.

Main Methods:

  • Immunohistochemical analysis using an anti-synaptophysin (SYP) antibody.
  • Examination of tissue samples from four cases of olivary hypertrophy and six control cases.

Related Experiment Videos

  • Microscopic evaluation of SYP immunoreactivity in neuronal cell bodies and neuropil.

    • Main Results:

    • An increased number of SYP-immunoreactive dots were observed on neuronal cell bodies in hypertrophied olives.
    • A decrease in SYP immunoreactivity was noted in the neuropil of the hypertrophied olives.
    • These findings indicate an altered distribution of presynaptic terminals in the inferior olivary nucleus during hypertrophy.

    Conclusions:

    • Synaptophysin expression patterns are significantly altered in olivary hypertrophy.
    • Presynaptic terminal distribution undergoes changes within the inferior olivary nucleus in this condition.
    • Further research is warranted to understand the functional implications of these synaptic alterations.