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Updated: Jul 16, 2026
06:20
Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Burkitt lymphoma presenting as a conjunctival mass
R W Weisenthal1, B W Streeten, A S Dubansky
1Department of Ophthalmology, State University of New York Health Science Center at Syracuse 13210.
Ophthalmology
|January 1, 1995
Summary
This case study reports the first conjunctival Burkitt lymphoma in a teen, successfully treated with chemotherapy. The study highlights diagnosis and management of this rare B-cell malignancy.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Burkitt lymphoma is a rare, aggressive non-Hodgkin lymphoma.
- Primary conjunctival involvement is exceptionally uncommon.
- Understanding pathogenesis and optimal management is crucial.
Observation:
- A 16-year-old presented with a rapidly growing conjunctival mass post-infectious mononucleosis.
- Biopsy confirmed Burkitt lymphoma, predominantly B-lymphocyte markers.
- Epstein-Barr virus (EBV) was detected in adenoidal tissue, not the tumor.
Findings:
- The conjunctival Burkitt lymphoma responded well to chemotherapy for localized non-Hodgkin lymphoma.
- The patient achieved disease-free status 4.5 years post-treatment.
- Absence of EBV in tumor cells suggests a non-contributory role in this sporadic case's oncogenesis.
Implications:
- This case expands the known sites of Burkitt lymphoma presentation.
- Chemotherapy remains the standard for stage 1 disease.
- Further research is needed to clarify EBV's role in sporadic Burkitt lymphoma pathogenesis.
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