[Treatment concept in infected bone and soft-tissue defects]
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Updated: Aug 18, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
1Chirurgische Klinik und Poliklinik, Klinikum Innenstadt, Ludwig-Maximilians-Universität.
Abstract:
The first priority when treating infected bone and soft-tissue defects is the maintenance or reconstruction of vitality, vascularity and stability. This means that when signs of infection are apparent, this is an immediate indication for operative revision with protective preparations on the tissue and radical debridement. Treatment of the soft-tissue damage is carried out with local or microsurgically connected muscle flaps. As for stability, in early infection the retention of well-bonded implants is often possible. If not, it is often necessary to change over to external fixation. Reconstruction of bone damage is carried out after the infection recedes, and complete healing is finally achieved by further treatment changes to conservative means or further stabilizing treatment.
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