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Related Experiment Videos

[Cortico-basal degeneration: a new entity]

P Gras1, E Creisson, M Giroud

  • 1Service de Rééducation et de Réadaptation fonctionnelle, CHRU de Dijon.

Presse Medicale (Paris, France : 1983)
|December 3, 1994
PubMed
Summary

Cortico-basal degeneration (CBD) is a progressive neurological disorder affecting both the brain cortex and basal ganglia. Early symptoms often involve one-sided movement and coordination issues, with brain scans showing asymmetric dysfunction.

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Area of Science:

  • Neuroscience
  • Neurology
  • Pathology

Context:

  • Cortico-basal degeneration (CBD) is a rare, progressive neurodegenerative disorder.
  • It presents with a combination of cortical and basal ganglia dysfunction.
  • Clinical manifestations are often asymmetric, predominantly affecting one body side at disease onset.

Purpose:

  • To describe the characteristic clinical, functional, and neuropathological features of Cortico-basal degeneration.
  • To highlight the asymmetric nature of the disease at its onset.
  • To underscore the need for further research into its relationship with other neurodegenerative diseases.

Summary:

  • CBD involves akineto-rigid syndrome and apraxia, often starting unilaterally, particularly on the left.
  • Other potential symptoms include myoclonus, chorea, and alien limb syndrome.

Related Experiment Videos

  • Brain imaging reveals asymmetric hypometabolism in cortical and basal structures, with neuropathology showing neuronal loss, gliosis, and achromasia in affected areas.

    • Impact:

    • Provides a comprehensive overview of Cortico-basal degeneration for clinicians and researchers.
    • Emphasizes the diagnostic challenges due to asymmetric presentation.
    • Suggests future research directions for understanding CBD's place within the spectrum of neurodegenerative diseases, such as progressive supranuclear palsy and Pick's disease.