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Relation of plasma coagulation factor VII and fibrinogen to carotid artery intima-media thickness
M N Sosef1, J G Bosch, J van Oostayen
1Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands.
Insights
Plasma clotting factors VII and fibrinogen do not impact early atherosclerosis in healthy adults. Carotid intima-media thickness, a marker of atherosclerosis, was not associated with these factors in this study.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Medical Imaging
Background:
- Plasma clotting factor VII and fibrinogen are implicated as risk factors for occlusive cardiovascular disease.
- Early atherosclerosis, preceding arterial thrombosis, requires investigation into potential contributing factors.
Purpose of the Study:
- To determine if coagulation parameters, specifically factor VII and fibrinogen, influence early atherosclerosis.
- To assess the relationship between carotid intima-media thickness and these coagulation factors in healthy volunteers.
Main Methods:
- High-resolution quantitative ultrasonography was employed to measure carotid intima-media thickness in 121 healthy individuals (aged 18-56).
- Associations were analyzed between intima-media thickness and classical cardiovascular risk factors (age, sex, cholesterol, smoking, blood pressure).
- The impact of factor VII and fibrinogen plasma levels and gene polymorphisms on intima-media thickness was investigated using multivariate linear regression.
Main Results:
- Classical risk factors, excluding smoking and family history, were associated with intima-media thickness.
- Age, blood pressure, and cholesterol were identified as independent determinants of intima-media thickness.
- Plasma levels of factor VII and fibrinogen showed no significant association with carotid intima-media thickness in multivariate analysis.
Conclusions:
- Carotid intima-media thickness measurement via ultrasound is a valuable method for studying early atherosclerosis.
- Plasma factor VII and fibrinogen levels are not associated with subclinical atherosclerotic changes in young to middle-aged healthy adults.
Abstract:
Plasma clotting factor VII and plasma fibrinogen have been claimed as independent risk factors for occlusive cardiovascular disease. The aim of this study was to investigate whether these coagulation parameters affect early atherosclerosis, additional to their possible effect on arterial thrombosis. We used high-resolution quantitative ultrasonography to measure carotid intima-media thickness in 121 healthy volunteers, aged 18 to 56 years. It has previously been demonstrated that an increased artery wall thickness is seen in advanced atherosclerosis. To validate our methodology for relatively young individuals, we assessed the association of intima-media thickness with the risk-factor status of our subjects, by including classical cardiovascular risk factors, e.g. age, sex, serum cholesterol, smoking habits and blood pressure. Thereafter, we studied the effect of factor VII and fibrinogen plasma levels on carotid intima-media thickness, as well as that of polymorphisms of the factor VII and fibrinogen genes. All classical risk factors except smoking and family history were associated with intima-media thickness. When adjusted for by multivariate linear regression analysis, age, blood pressure and cholesterol appeared to be independent determinants of intima-media thickness. Factor VII and fibrinogen levels showed no association in multivariate analysis with intima-media thickness. We conclude that artery wall thickness measurement by ultrasound is a useful tool to investigate the role of clotting factors in early atherosclerosis. Factor VII and fibrinogen levels in young and middle-aged volunteers have no association with early artherosclerotic vessel wall changes.