[The efficacy of replacement therapy in hypothyroidism]

The use of L-thyroxin in the substitution therapy for hypothyrosis is, in our judgement, a most pathogenetically well-grounded option. In the early period of the treatment of hypothyrosis with L-thyroxin the total clearance of thyroxin is accelerated and is in inverse relationship to the initial blood hormone level. From the results of pharmacokinetic studies a specific individualized regimen is proposed of thyroxin administration in the early period of the treatment of hypothyrosis, which allows the thyroxin concentrations to be achieved within the range of 120-150 micrograms. The use of the above method results in clearing up pathognomonic symptomatology of hypothyrosis, normalization of the thyrotrophin and total cholesterin levels, improvement in central hemodynamics in 14-21 days, promotes complete rehabilitation of patients about 1 month after the initiation of treatment.