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Simultaneous onset of Vogt-Koyanagi-Harada syndrome in monozygotic twins
A R Rutzen1, G Ortega-Larrocea, I R Schwab
1Doheny Eye Institute, Los Angeles, CA 90033.
American Journal of Ophthalmology
|February 1, 1995
Purpose/Methods:
We examined monozygotic twins of Vietnamese ancestry in whom the Vogt-Koyanagi-Harada syndrome developed.
Results/Conclusions:
Both patients demonstrated typical clinical findings of the Vogt-Koyanagi-Harada syndrome, and HLA typing disclosed HLA-DR4, an antigen that is present in a disproportionate number of patients with the Vogt-Koyanagi-Harada syndrome. Although familial cases of the Vogt-Koyanagi-Harada syndrome are rare, associations with HLA antigens may indicate that genetic factors play a role in this disease.