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Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro
M Loukovaara1, M Carson, H Adlercreutz
1Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland.
Biochemical and Biophysical Research Communications
|January 26, 1995
Abstract:
The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2- and 16 alpha-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.