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Vitamin A status in preterm neonates with and without chronic lung disease

S Chabra1, J D Arnold, G I Leslie

  • 1Department of Neonatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Journal of Paediatrics and Child Health
|October 1, 1994
PubMed

Insights

Vitamin A (VA) status in preterm infants showed no significant difference between those who developed chronic lung disease (CLD) and those who did not. Most infants had adequate VA levels, but some were deficient.

Area of Science:

  • Neonatology
  • Nutritional Science
  • Pediatric Pulmonology

Background:

  • Vitamin A (VA) deficiency is hypothesized to contribute to chronic lung disease (CLD) in preterm infants.
  • Understanding VA status is crucial for managing preterm infant health outcomes.

Purpose of the Study:

  • To assess vitamin A status in preterm infants.
  • To compare VA status between preterm infants who developed CLD and those who did not.

Main Methods:

  • Plasma vitamin A (VA), retinol binding protein (RBP), and the VA:RBP molar ratio were measured.
  • Measurements were taken in 25 infants with <31 weeks gestation during the first 28 days of life.
  • Infants were divided into two groups: those who developed CLD (n=11) and those who did not (n=14).

Main Results:

  • No significant difference in plasma VA levels was observed between the CLD and non-CLD groups within the first 28 days.
  • The majority of preterm infants in the study exhibited adequate vitamin A status.
  • A subset of infants were identified as vitamin A deficient.

Conclusions:

  • The study did not find a significant association between vitamin A status and the development of CLD in preterm infants within the first 28 days.
  • While most infants had sufficient VA levels, targeted monitoring for deficiency in subgroups may be warranted.

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