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Continuation ECT: relapse prevention in affective disorders

G Petrides1, D Dhossche, M Fink

  • 1Department of Psychiatry and Behavioral Sciences, School of Medicine, SUNY Stony Brook.

Convulsive Therapy
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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Continuation electroconvulsive therapy (C-ECT) can reduce relapse rates in patients with affective disorders. This study found C-ECT demonstrated a sustained prophylactic effect, lowering relapse rates compared to other treatments.

Area of Science:

  • Psychiatry
  • Neurology
  • Clinical Medicine

Background:

  • High relapse rates (50-95%) are common after acute treatment of affective disorders with medication or electroconvulsive therapy (ECT).
  • Preventive pharmacotherapy often fails to fully prevent relapse.
  • Continuation electroconvulsive therapy (C-ECT) is sometimes used after successful acute ECT treatment.

Purpose of the Study:

  • To evaluate the effectiveness of continuation electroconvulsive therapy (C-ECT) in preventing relapse in patients with affective illnesses.
  • To assess the one-year relapse rate for patients receiving C-ECT.
  • To compare relapse rates in patients with delusional depression treated with C-ECT versus those on continuation pharmacotherapy.

Main Methods:

  • Retrospective chart review of patients with affective illnesses who received C-ECT between 1985 and 1991.

Related Experiment Videos

  • Analysis of 33 courses of C-ECT with a mean intertreatment interval of 10.1 days and average treatment duration of 10 weeks.
  • One-year follow-up data collected for 21 patients.

    • Main Results:

    • Seven out of 21 patients (33%) relapsed and required re-admission within one year.
    • The relapse rate for patients with delusional depression was 42%.
    • This rate was significantly lower than the 95% relapse rate reported for delusional depression patients on continuation pharmacotherapy prior to the C-ECT program.

    Conclusions:

    • Continuation electroconvulsive therapy (C-ECT) demonstrated a sustained prophylactic effect for one year post-index episode.
    • C-ECT appears to be an effective strategy for relapse prevention in certain affective disorders, particularly delusional depression.
    • No other examined factor was a significant predictor of relapse, highlighting C-ECT's role.