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Limbic system fos expression associated with paternal behavior

B Kirkpatrick1, J W Kim, T R Insel

  • 1Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228.

Brain Research
|September 26, 1994
PubMed
Summary
This summary is machine-generated.

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The medial nucleus of the amygdala (MeA) is crucial for paternal behavior in prairie voles. Pup exposure increases Fos expression in the MeA and connected brain regions in males, indicating neural activation.

Area of Science:

  • Neuroscience
  • Behavioral Endocrinology
  • Animal Behavior

Background:

  • The medial nucleus of the amygdala (MeA) plays a role in male parental behavior in prairie voles.
  • Previous research indicates that lesions in the MeA decrease paternal care.

Purpose of the Study:

  • To further investigate the role of the amygdala in paternal behavior.
  • To identify brain regions activated during pup exposure in prairie voles.

Main Methods:

  • Male and female prairie voles were exposed to pups or non-social olfactory stimuli for 3 hours.
  • Immunocytochemistry was used to label cells expressing Fos peptide, a marker of neural activity.

Main Results:

  • Males exposed to pups showed increased Fos expression in the MeA and connected areas, including the accessory olfactory bulb, lateral septum, medial preoptic area, medial bed nucleus of the stria terminalis, nucleus reuniens, and paraventricular nucleus of the thalamus.

Related Experiment Videos

  • Females showed a similar pattern of Fos expression, but with less magnitude in the medial preoptic area and no significant increase in the thalamic paraventricular nucleus.
  • No significant Fos increase was observed in the paraventricular nucleus of the hypothalamus or piriform cortex.

    • Conclusions:

    • The medial nucleus of the amygdala (MeA) is involved in the neural control of paternal behavior.
    • Brain regions previously associated with maternal behavior may also contribute to paternal behavior regulation in prairie voles.