Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epigenetic effects in eukaryotic gene expression

T H Bestor1, V L Chandler, A P Feinberg

  • 1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.

Developmental Genetics
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of haplotype-dependent allele-specific DNA methylation in WGBS data.

Nature communications·2020
Same author

Common DNA methylation alterations in multiple brain regions in autism.

Molecular psychiatry·2013
Same author

Dropping device for cylinder plate assay of penicillin.

Science (New York, N.Y.)·2010
Same author

Epigenetic memory in induced pluripotent stem cells.

Nature·2010
Same author

Nanoelectromechanics of methylated DNA in a synthetic nanopore.

Biophysical journal·2009
Same author

Gene regulation: stochastic and deterministic effects in gene regulation.

Heredity·2007

Epigenetic phenomena in eukaryotes involve chromatin states and methylation patterns. Studying gene inactivation in various organisms offers new hypotheses for mammalian epigenetics research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Epigenetic phenomena in eukaryotes are crucial for inheritance.
  • Understanding chromatin states and methylation patterns is key.
  • Higher-order chromatin structure assembly remains challenging for biochemical methods.

Purpose of the Study:

  • To explore the role of epigenetic phenomena in eukaryotes.
  • To gain insights into the structure and assembly of higher-order chromatin.
  • To leverage findings from model organisms for mammalian research.

Main Methods:

  • Analysis of epigenetic phenomena across eukaryotes.
  • Investigating gene inactivation in fungi, plants, and invertebrates.
  • Formulating hypotheses for mammalian epigenetic studies.

Related Experiment Videos

Main Results:

  • Epigenetic inheritance relies on chromatin states and methylation.
  • Higher-order chromatin structure is a complex area of study.
  • Gene inactivation studies in non-mammals provide valuable insights.

Conclusions:

  • Epigenetic phenomena are fundamental to eukaryotic inheritance.
  • Further research into chromatin structure is needed.
  • Comparative studies across diverse organisms advance epigenetic understanding.