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Insulin sensitivity in post-obese women
1Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Clinical Science (London, England : 1979)
|October 1, 1994
Summary
Insulin sensitivity for glucose metabolism remains unchanged in post-obese women. However, they exhibit increased insulin action against fat breakdown, potentially promoting fat storage and reducing lipid oxidation.
Area of Science:
- Metabolic Physiology
- Endocrinology
- Obesity Research
Background:
- Insulin resistance is a hallmark of obesity, but its role in the post-obese state is debated.
- Both increased and decreased insulin sensitivity have been hypothesized to precede obesity development.
Purpose of the Study:
- To investigate insulin sensitivity in weight-stable post-obese women compared to matched controls.
- To assess glucose and lipid metabolism in post-obese individuals.
Main Methods:
- A hyperinsulinemic euglycemic glucose clamp was performed for 2 hours.
- Indirect calorimetry was used to measure substrate oxidation rates.
- Measurements were conducted in nine post-obese women and nine control women after a standardized diet and fasting period.
Main Results:
- Glucose disposal rate and glucose oxidation were similar between post-obese and control women.
- Lipid oxidation decreased similarly in both groups during the clamp.
- Post-obese women had significantly lower plasma free fatty acid concentrations at the end of the clamp compared to controls (P=0.02).
Conclusions:
- Insulin sensitivity of glucose metabolism is not altered in the post-obese state.
- Post-obese subjects display enhanced antilipolytic insulin action.
- This increased antilipolytic effect may contribute to fat storage and reduced postprandial lipid oxidation.