Related Experiment Videos
Epidermal growth factor induces serine phosphorylation of actin
S van Delft1, A J Verkleij, J Boonstra
1Department of Molecular Cell Biology, Utrecht University, The Netherlands.
FEBS Letters
|January 9, 1995
Abstract:
Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.