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Commingling analysis of memory performance in elderly men

C G Palmer1, B H Wolkenstein, A La Rue

  • 1Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles.

Genetic Epidemiology
|January 1, 1994
PubMed
Summary

This study investigated memory performance in elderly males, finding a low-scoring cluster suggesting a genetic link to dementia of the Alzheimer type (DAT). This may help identify individuals at risk for DAT gene carriers.

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Area of Science:

  • Neuroscience
  • Genetics
  • Epidemiology

Background:

  • Dementia of the Alzheimer type (DAT) may have a genetic component.
  • Previous research suggested two genotypic subgroups (carriers/non-carriers) based on memory performance in DAT offspring.
  • A prediction was that the general elderly population would also show two memory performance distributions.

Purpose of the Study:

  • To test the hypothesis of two memory performance distributions in the general elderly population.
  • To investigate if memory performance differences correlate with DAT risk.
  • To explore the potential for identifying carriers of a putative DAT gene.

Main Methods:

  • Analyzed memory performance (Benton visual retention test) in 1,149 normal elderly males (mean age 71.4).

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  • Utilized commingling analyses to examine the distribution of memory scores.
  • Assessed for skewness and the fit of single versus mixture distributions.

    • Main Results:

    • The distribution of memory performance showed significant negative skewness.
    • A single normal distribution required transformation; however, two distributions fit better without transformation.
    • Approximately 6% of subjects fell into a "low"-scoring cluster.

    Conclusions:

    • Findings support the hypothesis of two memory performance distributions in the general elderly population.
    • Memory performance differences may indicate premorbid or morbid differences related to DAT.
    • This could aid in identifying at-risk carriers of a major DAT gene.