Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation

E Garpestad1, J A Parker, H Katayama

  • 1Charles A. Dana Institute, Beth Israel Hospital, Boston, Massachusetts.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of the colistin resistance gene mcr-1 with faecal pollution in water environments in Hanoi, Vietnam.

Letters in applied microbiology·2020
Same author

Ozone disinfection kinetics of poliovirus 1 determined by cell culture assay, RT-qPCR and ethidium monoazide qPCR reduction in a continuous quench-flow reactor.

Journal of applied microbiology·2020
Same author

Combination gemcitabine plus S-1 versus gemcitabine plus cisplatin for advanced/recurrent biliary tract cancer: the FUGA-BT (JCOG1113) randomized phase III clinical trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

The State Scientific Automated Medical Registry, Kazakhstan: an important resource for low-dose radiation health research.

Radiation and environmental biophysics·2018
Same author

Surrogacy of progression-free survival (PFS) for overall survival (OS) in esophageal cancer trials with preoperative therapy: Literature-based meta-analysis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
Same author

Combined reconstructive surgery involving uterosacral colpopexy and anterior vaginal mesh implantation for pelvic organ prolapse.

The journal of obstetrics and gynaecology research·2016
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Obstructive sleep apnea causes changes in blood pressure and heart function during sleep recovery. These hemodynamic changes may result from distinct mechanisms, not solely from low oxygen levels or sleep arousal.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Physiology

Background:

  • Obstructive sleep apnea (OSA) is linked to nocturnal hemodynamic changes.
  • Apnea recovery involves decreased oxygen saturation, altered intrathoracic pressure, and arousal.

Purpose of the Study:

  • To differentiate the effects of hypoxemia and arousal on cardiac function during OSA recovery.
  • To understand the physiological mechanisms behind hemodynamic oscillations in OSA patients.

Main Methods:

  • Measured left ventricular stroke volume (LVSV) and mean arterial pressure (MAP) in severe OSA patients.
  • Compared hemodynamic responses during normal apnea recovery with supplemental oxygen (maintaining SaO2 > 90%).
  • Assessed hemodynamic responses during arousal from sleep using nasal continuous positive airway pressure (CPAP).

Related Experiment Videos

Main Results:

  • Apnea recovery increased MAP and decreased LVSV, irrespective of supplemental oxygen.
  • Nasal CPAP-induced arousal elevated MAP but did not replicate the LVSV decrease seen in natural recovery.
  • The magnitude of cardiac function reduction at apnea termination was not fully reproduced by arousal alone.

Conclusions:

  • Hemodynamic changes at apnea termination in OSA patients involve multiple physiological mechanisms.
  • Both hypoxemia and arousal contribute to elevated blood pressure, but LVSV reduction may have different triggers.