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Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
The selection index--then, now, and for the future
L N Hazel1, G E Dickerson, A E Freeman
1Agricultural Research Service, University of Nebraska, Lincoln 68583-0908.
Journal of Dairy Science
|October 1, 1994
Summary
Simultaneous multiple-trait index selection is more effective for improving multiple traits than other methods. This approach defines aggregate breeding value using trait breeding values and economic importance for optimized genetic gains.
Area of Science:
- Animal breeding and genetics
- Quantitative genetics
Background:
- Selecting for multiple traits with varying characteristics (variability, heritability, economic importance, correlations) presents challenges.
- Traditional selection methods like independent culling and sequential selection may not be optimal for complex breeding goals.
Purpose of the Study:
- To compare the effectiveness of simultaneous multiple-trait index selection against independent culling and sequential selection.
- To define the methodology for establishing aggregate breeding values and economic weights for effective multi-trait selection.
Main Methods:
- Defined aggregate breeding value based on individual trait breeding values and their economic importance.
- Proposed economic weights approximating the partial regression of enterprise output value on trait breeding value.
- Utilized Best Linear Unbiased Prediction (BLUP) for regressed breeding value predictions, accounting for varying information and unknown means.
Main Results:
- Simultaneous multiple-trait index selection demonstrated greater effectiveness than independent culling or sequential selection for improving multiple traits.
- The proposed method for defining economic weights and aggregate breeding values allows for optimized selection across different age classes.
- BLUP predictions facilitate accurate application of economic weights and selection proportions to maximize genetic gain.
Conclusions:
- Simultaneous multiple-trait index selection is superior for achieving genetic improvement across multiple traits with diverse characteristics.
- Accurate definition of economic weights and utilization of BLUP-predicted breeding values are crucial for maximizing aggregate genetic gain.
- This approach enhances the efficiency of selection programs, particularly in crossbreeding systems and for maintaining competitive genetic merit.
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