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Biodegradable controlled antibiotic release devices for osteomyelitis: optimization of release properties
1Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.
The Journal of Pharmacy and Pharmacology
|September 1, 1994
Summary
Biodegradable polymer devices for controlled antibiotic release were developed for osteomyelitis treatment. Coated cylinders with 20-30% gentamicin showed promising sustained release, adjustable by length.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Osteomyelitis treatment requires effective local antibiotic delivery.
- Biodegradable polymers offer potential for controlled drug release devices.
- Poly(D,L-lactide) (PDLLA) and poly(D,L-lactide-co-epsilon-caprolactone) were investigated for antibiotic delivery.
Purpose of the Study:
- To develop and evaluate biodegradable polymer devices for controlled release of gentamicin sulphate for osteomyelitis treatment.
- To investigate the in-vitro release properties of different device formulations and drug loadings.
Main Methods:
- Fabrication of controlled antibiotic release films, melt-extruded cylinders, and suspension-extruded/coated cylinders using PDLLA and poly(D,L-lactide-co-epsilon-caprolactone).
- In-vitro release studies of gentamicin sulphate from devices with varying drug loadings (16-50%).
- Evaluation of device integrity and release kinetics under different conditions.
Main Results:
- Films and melt-extruded cylinders showed rapid initial burst and incomplete release.
- Some polymer formulations degraded prematurely, affecting release.
- PDLLA-coated cylinders with 20-30% gentamicin loading exhibited a small initial burst and sustained release.
- Release duration from coated cylinders was tunable by adjusting cylinder length.
Conclusions:
- Biodegradable polymer devices, particularly PDLLA-coated cylinders, show promise for sustained gentamicin release in osteomyelitis treatment.
- The release rate and duration can be precisely controlled by adjusting drug loading and device dimensions.
- These findings offer a customizable approach to antibiotic delivery for patient-specific needs.
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