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Autonomic dysfunction in diffuse scleroderma vs CREST: an assessment by computerized heart rate variability

A G Hermosillo1, R Ortiz, J Dábague

  • 1Department of Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, DF.

The Journal of Rheumatology
|October 1, 1994
PubMed
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Patients with CREST syndrome exhibit reduced heart rate variability, indicating decreased parasympathetic control compared to diffuse scleroderma. This autonomic dysfunction may serve as a marker for adverse outcomes in scleroderma.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Rheumatology

Background:

  • Autonomic dysfunction is a known complication in scleroderma.
  • Heart rate variability (HRV) assesses the balance between sympathetic and parasympathetic nervous system activity.
  • Understanding autonomic control in scleroderma subtypes is crucial for risk stratification.

Purpose of the Study:

  • To investigate differences in heart rate variability between CREST syndrome and diffuse scleroderma.
  • To determine if HRV can serve as a marker for autonomic dysfunction in scleroderma subtypes.
  • To explore the impact of autonomic imbalance on cardiac outcomes in scleroderma.

Main Methods:

  • Short-term analysis of heart rate variability (HRV).
  • Study included 9 patients with diffuse scleroderma, 8 with CREST syndrome, and 17 healthy controls.

Related Experiment Videos

  • Comparison of HRV parameters including standard deviation of R-R intervals and power spectrum analysis.

    • Main Results:

    • Patients with CREST syndrome demonstrated abnormal HRV.
    • Reduced standard deviation of R-R intervals and low power spectrum density were observed in CREST patients.
    • Significant reductions in total power and high-frequency components of HRV were noted in CREST syndrome.

    Conclusions:

    • CREST syndrome is associated with decreased parasympathetic control of heart rate.
    • This autonomic dysfunction in CREST differs significantly from that in diffuse scleroderma.
    • Further research is needed to establish the clinical relevance of these HRV differences in scleroderma subsets.