Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural similarity between two-layer alpha/beta and beta-proteins

A V Efimov1

  • 1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region.

Journal of Molecular Biology
|January 27, 1995
PubMed
Summary

Common folding principles govern diverse protein structures. Recurrent abcd-units and simple rules explain the formation of alpha/beta-proteins and beta-proteins, suggesting physical laws drive protein folding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Chordoma as a neurosurgical pathology].

Arkhiv patologii·2022
Same author

[Relationship between the Interhelical Packing Angles and the Length of α-Helices in Proteins].

Molekuliarnaia biologiia·2020
Same author

[Structure and Features of Amino Acid Sequences of L-Modules in SH3-Like Folds].

Molekuliarnaia biologiia·2019
Same author

Chirality and Handedness of Protein Structures.

Biochemistry. Biokhimiia·2018
Same author

[Unique Combinations of βαβ-Units and Π-Like Modules in Proteins and Specific Features of Their Amino Acid Sequences].

Molekuliarnaia biologiia·2018
Same author

[Relationship between structure and amino acid sequence of strongly twisted and coiled β-hairpins in globular proteins].

Molekuliarnaia biologiia·2016

Area of Science:

  • Structural biology
  • Protein folding
  • Biophysics

Background:

  • Proteins fold into diverse structures with varied functions.
  • Two-layer alpha/beta-proteins and beta-proteins exhibit distinct structural classes.

Purpose of the Study:

  • To identify common structural features and folding principles in alpha/beta-proteins and beta-proteins.
  • To explore the physical basis of protein folding similarities across different protein classes.

Main Methods:

  • Comparative analysis of known protein structures.
  • Identification of recurrent folding units (abcd-units).
  • Application of three simple folding rules to predict protein structures.

Main Results:

Related Experiment Videos

  • Common recurrent folding units (abcd-units) are found in both protein classes.
  • Larger common structural motifs are observed across diverse proteins.
  • Protein structures can be generated by stepwise addition of elements to abcd-units following specific rules.

    • Conclusions:

    • Physical principles, not just evolution, dictate protein folding similarities.
    • Simple rules govern the assembly of secondary structure elements into complex protein folds.
    • Protein environment influences polypeptide chain conformation selection.