[Anesthetic management of a patient with adrenocorticotropic hormone (ACTH) deficiency]

A 73 year old woman with ACTH deficiency was admitted to our hospital for gastrectomy. She had taken corticosteroid for 3 years. The day before surgery, she took 25 mg of hydrocortisone per os. Hydrocortisone 100 mg was administered intravenously 30 minutes before surgery, during and after surgery, and on the next day after surgery. Serum concentrations of ACTH and cortisol were measured 1 hour after the first administration of hydrocortisone 100 mg, 2 hours after the second and 15 hours after the third administration. The ACTH concentration was always lower than the lowest limit of detection. Cortisol concentrations were 140.0, 180.0 and 14.5 micrograms.dl-1 at each measurement. Serum concentration of aldosterone after the induction of anesthesia was lower than the normal range. Her hemodynamics were very stable and electrolytes balance was not disturbed with corticosteroid treatment during and after surgery.