Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The epidermal growth factor family]

E Nexø1

  • 1Arhus Kommunehospital, klinisk-biokemisk afdeling KH.

Ugeskrift for Laeger
|November 7, 1994
PubMed
Summary

Epidermal growth factor (EGF) peptides and their receptors are crucial for cell growth, tissue repair, and fetal development. Aberrant EGF system signaling is implicated in various cancers, including glioblastomas and breast cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early changes in vitamin B12 uptake and biomarker status following Roux-en-Y gastric bypass and sleeve gastrectomy.

Clinical nutrition (Edinburgh, Scotland)·2018
Same author

Absorption and retention of free and milk protein-bound cyano- and hydroxocobalamins. An experimental study in rats.

Biochimie·2015
Same author

Metformin increases liver accumulation of vitamin B12 - an experimental study in rats.

Biochimie·2013
Same author

PET imaging of patients with non-small cell lung cancer employing an EGF receptor targeting drug as tracer.

British journal of cancer·2011
Same author

Haptocorrin as marker of disease progression in fibrolamellar hepatocellular carcinoma.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2010
Same author

Increased prevalence of autoimmunity in Turner syndrome--influence of age.

Clinical and experimental immunology·2009

Area of Science:

  • Cell biology
  • Molecular biology
  • Oncology

Background:

  • Cellular growth and differentiation are regulated by growth factors binding to specific cell membrane receptors.
  • The epidermal growth factor (EGF) family comprises nine peptides activating four EGF receptors (HER-1-4).
  • This system is vital for fetal development, tissue repair, and implicated in malignant diseases.

Purpose of the Study:

  • To investigate the role of the EGF system in human tumors.
  • To analyze the expression of EGF and its receptors in various cancer types.

Main Methods:

  • Analysis of the epidermal growth factor system in human tumor samples.
  • Assessing the expression levels of EGF peptides and their receptors.

Main Results:

  • The EGF system, including receptors HER-1-4, is present in nearly all body cells.
  • Elevated expression of the EGF system was observed in glioblastomas, mammary cancers, head and neck carcinomas, and bladder cancer.
  • EGF treatment has shown utility in repairing gastrointestinal and corneal lesions.

Conclusions:

  • The epidermal growth factor system plays a significant role in both normal physiological processes and the development of various cancers.
  • Understanding EGF system dysregulation is critical for cancer diagnosis and therapeutic strategies.

Related Experiment Videos