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Baclofen poisoning in children
1Department of Paediatrics and Child Health, University of Cape Town, Rondebosch, South Africa.
Veterinary and Human Toxicology
|October 1, 1994
Summary
Acute baclofen overdose in children causes rapid central nervous system and respiratory depression. Supportive care effectively managed all cases, highlighting the need for safe medication storage.
Area of Science:
- Pediatric Toxicology
- Emergency Medicine
- Pharmacology
Background:
- Baclofen (Lioresal) is a muscle relaxant prescribed for spasticity.
- Accidental overdose in children poses significant risks.
- Understanding overdose effects is crucial for timely intervention.
Observation:
- Six pediatric cases of acute baclofen overdose were analyzed.
- All patients exhibited central nervous system depression.
- Respiratory depression, agitation, convulsions, and ataxia were observed.
Findings:
- Rapid onset of CNS and respiratory depression was a consistent finding.
- All children recovered with supportive management.
- Accurate quantification of ingested baclofen was not feasible.
Implications:
- Emphasizes the critical need for enhanced education on safe drug storage and disposal practices for households with children.
- Highlights the effectiveness of supportive care in managing baclofen overdose.
- Underscores the importance of prompt recognition and management of baclofen toxicity in pediatric patients.