Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucosal mast cells and developmental changes in gastric absorption

A G Catto-Smith1, J L Ripper

  • 1Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia.

The American Journal of Physiology
|January 1, 1995
PubMed
Summary

Gastric mast cells degranulate during rat postnatal development, increasing stomach permeability and macromolecule absorption. This suggests mast cell activity influences neonatal gut barrier function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Education and imaging. Gastrointestinal: botulinum toxin effective in refractory gastroparesis in paediatric practice.

Journal of gastroenterology and hepatology·2015
Same author

Gut flora and mucosal function.

Asia Pacific journal of clinical nutrition·2014
Same author

Enteral nutrition in Crohn's disease: an underused therapy.

Gastroenterology research and practice·2014
Same author

Novel Burkholderiales 23S rRNA genes identified in ileal biopsy samples from children: preliminary evidence that a subtype is associated with perianal Crohn's disease.

Journal of clinical microbiology·2010
Same author

Hypnotherapy for treatment of irritable bowel syndrome.

The Cochrane database of systematic reviews·2007
Same author

Effect of gluten-free diet and adherence on growth and diabetic control in diabetics with coeliac disease.

Archives of disease in childhood·2004

Area of Science:

  • Gastroenterology
  • Developmental Biology
  • Immunology

Background:

  • Neonatal gastrointestinal development involves complex physiological changes.
  • Gastric mucosal mast cells play roles in immune responses and gut function.

Purpose of the Study:

  • To investigate gastric mucosal mast cell degranulation during postnatal development in rats.
  • To correlate mast cell activity with gastric electrical parameters, permeability, and macromolecular absorption.

Main Methods:

  • Histological analysis and measurement of rat mast cell protease II levels.
  • Assessment of short-circuit current, transepithelial conductance, and permeability in voltage-clamped stomachs.
  • Evaluation of macromolecular uptake and in vitro mast cell degranulation effects.

Related Experiment Videos

Main Results:

  • Mast cell degranulation peaked around days 15-17 post-birth.
  • Gastric permeability and conductance transiently increased at 17 days, correlating with mast cell degranulation.
  • Macromolecular uptake was higher in younger rats (10-15 days).

Conclusions:

  • Gastric mucosal mast cells degranulate during normal postnatal development.
  • The neonatal rat stomach exhibits increased permeability and macromolecule absorption.
  • Mast cell degranulation during development may impact gastric mucosal permeability.