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Related Experiment Videos

Cardiorespiratory reflex control in rats with left ventricular dysfunction

R Jung1, M E Dibner-Dunlap, M A Gilles

  • 1Department of Medicine, University Hospitals of Cleveland, Ohio.

The American Journal of Physiology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Left ventricular dysfunction (LVD) impairs arterial baroreflexes, affecting sympathetic and heart rate control even without heart failure. This impairment is linked to infarct size and involves both afferent and central mechanisms.

Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Myocardial Infarction Research

Background:

  • Heart failure is characterized by neurohumoral activation and impaired baroreflex control.
  • Left ventricular dysfunction (LVD) can occur without overt congestive heart failure.
  • The role of baroreflex dysfunction in LVD without heart failure needs further investigation.

Purpose of the Study:

  • To determine if arterial baroreflexes are impaired in rats with LVD due to chronic myocardial infarction, independent of congestive heart failure.
  • To investigate the contribution of abnormal central mechanisms to this baroreflex impairment.

Main Methods:

  • Anesthetized rats with and without LVD were subjected to phenylephrine-induced increases in arterial pressure to stimulate baroreceptors.

Related Experiment Videos

  • Lumbar sympathetic nerve activity, phrenic nerve activity, and heart rate were recorded.
  • Central baroreflex function was assessed via electrical stimulation of the aortic depressor nerve.

    • Main Results:

    • Rats with moderate LVD exhibited impaired baroreflex control of sympathetic, ventilatory, and heart rate responses.
    • Baroreflex gains were inversely correlated with the size of the myocardial infarct.
    • Central gain for sympathetic nerve activity was also found to be impaired.

    Conclusions:

    • Arterial baroreflex control of the cardiorespiratory system is impaired in rats with moderate LVD, even in the absence of congestive heart failure.
    • Attenuated baroreflexes are likely caused by abnormal afferent mechanisms, with central mechanisms contributing to barosympathetic reflex impairment.