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Aging effects on human sympathetic neuronal function

M D Esler¹, A G Turner, D M Kaye

¹Baker Medical Research Institute, Prahran, Melbourne, Australia.

The American Journal of Physiology

|January 1, 1995

Summary

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Aging impairs sympathetic nervous function by reducing norepinephrine clearance and reuptake, particularly in the heart. This study investigated neurochemical changes in younger and older men to understand these age-related effects.

Area of Science:

Physiology
Neuroscience
Gerontology

Background:

Sympathetic nervous system function undergoes changes with aging.
Understanding these changes is crucial for managing age-related health conditions.

Purpose of the Study:

To investigate the impact of aging on human sympathetic nervous system function.
To quantify neurochemical changes related to sympathetic neurotransmission in younger versus older men.

Main Methods:

Applied kinetic methods to measure plasma fluxes of key neurochemicals.
Compared healthy men aged 20-30 years with those aged 60-75 years.
Utilized regional venous sampling and tritiated norepinephrine extraction.

Main Results:

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Older men had 66% higher plasma norepinephrine concentrations.
Norepinephrine plasma clearance was 22% lower in older men.
Increased cardiac norepinephrine spillover in older men was attributed to diminished reuptake, not increased nerve firing.

Conclusions:

Aging is associated with reduced norepinephrine clearance and neuronal reuptake.
Sympathetic outflow to organs is not globally activated by aging.
Altered cardiac norepinephrine handling in older adults is primarily due to impaired reuptake.