Visual callosal connections and strabismus

Strabismus is a condition that exists when the visual axes of the two eyes fail to intersect at the fixation point under binocular viewing conditions. When it occurs in mammals during the critical period which corresponds to the period of maximal plasticity early in life, strabismus is known to induce both morphological anomalies and abnormal connections from the retina to the cortex; it further leads to binocular neural changes and to spatial vision deficits, especially at the cortical level. After a brief review of the already known data about the consequences of early strabismus in cats, monkeys and humans on the development of the visual system and of visual perception, new data are presented here concerning interhemispheric connections in the cat. In normally-reared kittens, visual callosal transfer is shown to be almost adult-like as soon as 12 days after birth: it is almost limited to the 17/18 border of the visual cortex when using visual stimulations in spite of the presence of still numerous juvenile exuberant callosal projections. In contrast, callosal transfer of visual information is extended to both areas 17 and 18 after strabismus, leading to the conclusion that at least some juvenile exuberant callosal projections are not only anatomically but also functionally stabilized after such an oculomotor disease. The possibility that similar abnormalities might be present in monkeys and humans is discussed.