Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epithelial sodium transport: basic autoregulatory mechanisms

K Turnheim1

  • 1Institute of Pharmacology, Vienna University, Austria.

Physiological Research
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics of the local anesthetic ropivacaine after transversus abdominis plane block in healthy volunteers.

European journal of clinical pharmacology·2011
Same author

[Coxibs: cyclooxygenase-2 inhibitors].

Wiener klinische Wochenschrift·2001
Same author

Analgesic effects of caudal and intramuscular S(+)-ketamine in children.

Anesthesiology·2000
Same author

[Adverse effects of psychotropic drugs in the elderly].

Wiener klinische Wochenschrift·2000
Same author

Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects.

British journal of clinical pharmacology·1999
Same author

Membrane phospholipid composition affects function of potassium channels from rabbit colon epithelium.

The American journal of physiology·1999

Epithelial cells maintain stable intracellular sodium levels through coordinated apical entry and basolateral extrusion. This regulation involves the Na+,K+-ATPase pump and K+ conductance, potentially influenced by cell volume changes.

Area of Science:

  • Cellular Physiology
  • Epithelial Transport
  • Ion Homeostasis

Background:

  • Epithelial cells possess autoregulatory mechanisms to control intracellular sodium.
  • Maintaining constant intracellular sodium is crucial for cell function during altered transport rates.

Purpose of the Study:

  • To investigate the mechanisms coordinating apical sodium entry and basolateral sodium extrusion in epithelial cells.
  • To understand how Na+,K+-ATPase activity and K+ conductance are regulated during changes in active sodium transport.

Main Methods:

  • The study likely involved electrophysiological techniques to measure ion fluxes and membrane potentials.
  • Analysis of Na+,K+-ATPase activity and basolateral membrane properties.

Main Results:

Related Experiment Videos

  • Intracellular sodium activity is maintained constant despite changes in active sodium transport rates.
  • Basolateral Na+,K+-ATPase activity increases via more units and higher turnover per unit.
  • Basolateral K+ conductance parallels Na+ extrusion, termed "pump-leak parallelism".

Conclusions:

  • Autoregulation of apical Na+ entry and basolateral Na+ extrusion ensures intracellular ion stability.
  • Cell volume changes may play a role in coordinating membrane transport properties during stimulated active transport.