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Related Experiment Videos

The frontal lobes and schizophrenia

D R Weinberger1, M S Aloia, T E Goldberg

  • 1Clinical Brain Disorders Branch, National Institute of Mental Health, Neuroscience Center at St. Elizabeths, Washington, DC 20032.

The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1994
PubMed
Summary

Schizophrenia patients often exhibit frontal lobe dysfunction. Impaired prefrontal cortex connectivity may explain both cognitive deficits and psychotic symptoms in this condition.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia is frequently associated with frontal lobe dysfunction.
  • Clinical manifestations include blunted affect, impaired problem-solving, and impoverished thinking.

Purpose of the Study:

  • To present evidence of frontal abnormalities in schizophrenia.
  • To explore the link between frontal dysfunction and illness manifestations.

Main Methods:

  • Review of cytoarchitectural studies.
  • Analysis of neuropsychological data.
  • Examination of functional neuroanatomical evidence.

Main Results:

  • Evidence points to significant frontal lobe abnormalities in schizophrenia.

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  • Studies highlight issues with intracortical connectivity in the prefrontal cortex.

    • Conclusions:

    • Failure of prefrontal cortex intracortical connectivity is implicated.
    • This connectivity failure may underlie both cognitive and psychotic symptoms of schizophrenia.