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Verruciform xanthoma: an immunocytochemical study

G E Orchard1, E Wilson Jones, R Russell Jones

  • 1Dermatopathology Department, St John's Dermatology Centre, St Thomas's Hospital, London, England, UK.

British Journal of Biomedical Science
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

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Verruciform xanthoma cells originate from monocyte macrophages, as shown by immunocytochemical analysis. This study did not find evidence of human papilloma virus (HPV) involvement in these rare lesions.

Area of Science:

  • Dermatopathology
  • Immunohistochemistry
  • Oral Medicine

Background:

  • Verruciform xanthoma is a rare lesion occurring on oral mucosa, other mucosal sites, and skin.
  • The cellular origin and potential triggers of verruciform xanthoma remain areas of investigation.

Purpose of the Study:

  • To perform immunocytochemical analysis of xanthoma cells in verruciform xanthoma.
  • To investigate human papilloma virus (HPV) as a potential causative agent.

Main Methods:

  • Immunocytochemical analysis using a panel of histiocytic markers (CD68, KiM1P, HAM 56, lysozyme, vimentin, peanut agglutinin, factor X111a).
  • Detection assays for HPV (CAMVIR-1) and bovine papilloma virus-1 (BPV-1).
  • Analysis of three verruciform xanthoma cases (two vulval, one scrotal).

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Main Results:

  • Xanthoma cells showed positivity for CD68, KiM1P, HAM 56, and vimentin.
  • Less consistent positivity was observed for peanut agglutinin and lysozyme.
  • No evidence of HPV or BPV-1 involvement was found (CAMVIR-1 and BPV-1 negative).

Conclusions:

  • The findings support a monocyte-macrophage lineage for verruciform xanthoma cells.
  • Human papilloma virus (HPV) is not demonstrated as a causative factor in these cases.