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[Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries]
1Department of Cardiothoracic Surgery, Second Affiliated Hospital, Hunan Medical University, Changsha.
Insights
Ginsenoside protects the heart during open-heart surgery. Both total Ginsenoside and Ginsenoside Rb reduced myocardial injury, with total Ginsenoside showing superior protective effects against ischemic and reperfusion damage.
Area of Science:
- Cardiovascular Surgery
- Pharmacology
- Biochemistry
Background:
- Myocardial ischemic and reperfusion injuries are significant complications in open-heart surgery.
- Ginsenosides are being investigated for their cardioprotective properties.
Purpose of the Study:
- To evaluate the protective effects of total Ginsenoside and Ginsenoside Rb against myocardial ischemic and reperfusion injuries during mitral valvular surgery.
Main Methods:
- Randomized study of 30 mitral valvular surgical patients divided into three groups: control, total Ginsenoside, and Ginsenoside Rb.
- Intraoperative transesophageal echocardiography assessed cardiac function.
- Electromicroscopy examined myocardial cell ultrastructures.
Main Results:
- Both total Ginsenoside and Ginsenoside Rb demonstrated protective effects on myocardial ischemic and reperfusion injuries.
- Total Ginsenoside exhibited a more significant protective effect compared to Ginsenoside Rb.
Conclusions:
- Total Ginsenoside and Ginsenoside Rb are effective in mitigating myocardial damage during open-heart surgery.
- Total Ginsenoside offers superior cardioprotection compared to Ginsenoside Rb in this context.
Abstract:
Thirty mitral valvular surgical patients were randomly divided into three groups for study of protective effects of Ginsenoside on myocardiac ischemic and reperfusion injuries. In GI, 11 patients (controls), no Ginsenoside was used, in GII, 11, Ginsenoside in total was added into the cardioplegic solusion made in our hospital, and in GIII, 8, instead of Ginsenoside in total Ginsenoside Rb was added. During operation comparative studies were made of pre- and postoperative cardiac functions with intraoperative transesophageal echocardiography and ultrastructures of myocardiac cells with electromicroscopy. We conclude that both Ginsenoside in total and Ginsenoside Rb have protective effects on myocardiac ischemic and reperfusion injuries in open heart surgery, and the effect of Ginsenoside in total is even better than that of Ginsenoside Rb.