[Amplification of C-erB-2 oncogene in colon carcinomas]

Differential PCR has been used to detect the variance of c-erbB-2 gene copies in 23 colon carcinoma tissues. It was found that amplification of c-erbB-2 gene existed in 7 out of 23 (30%) cases. All of the three high-middle differentiated colon carcinomas had amplification of c-erbB-2 gene in our specimens. It was higher than that of the middle differentiated colon carcinomas (P < 0.05). The rate of amplification of c-erbB-2 gene in patients with positive lymph node was approximately two times as high as that in negative nodo patients, but this difference was not significant (P > 0.20).