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Inhaled diuretics attenuate acid-induced cough in children with asthma
H Mochizuki1, T Shimizu, A Morikawa
1Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan.
Insights
Inhaled diuretics furosemide and amiloride effectively reduced cough in asthmatic children challenged with acid. This suggests a potential new therapeutic approach for cough in asthma.
Area of Science:
- Pulmonology
- Pediatric Asthma Research
- Respiratory Pharmacology
Background:
- Cough is a common symptom in pediatric asthma.
- Acid-induced cough is a specific challenge in asthmatic patients.
- Inhaled diuretics have not been extensively studied for cough suppression in asthma.
Purpose of the Study:
- To investigate the efficacy of inhaled furosemide and amiloride in preventing acid-induced cough in children with asthma.
- To assess the protective effects of these diuretics against acetic acid challenge.
Main Methods:
- A double-blind, randomized, placebo-controlled study was performed.
- 12 asthmatic children inhaled furosemide, amiloride, or placebo before an acetic acid challenge.
- Cough response and bronchoconstriction were monitored.
Main Results:
- Both inhaled furosemide and amiloride significantly reduced acetic acid-induced cough in asthmatic children (p < 0.01 and p < 0.05, respectively).
- No bronchoconstriction was observed after diuretic administration.
- There was a weak correlation between the protective effects of furosemide and amiloride.
Conclusions:
- Inhaled furosemide and amiloride can attenuate acid-induced cough in asthmatic children.
- The protective mechanism may not solely rely on the Na(+)-K(+)-Cl- cotransporter or Na+ channels.
- Inhaled diuretics represent a potential therapeutic option for managing cough in pediatric asthma.
Abstract:
To evaluate the effect of inhaled diuretics, furosemide and amiloride, on cough induced by acid inhalation challenge in asthmatic children, a double-blind, randomized, placebo-controlled study was conducted. On separate days, 12 asthmatic children (10.3 +/- 0.7 [SEM] years) underwent acetic acid (AD) inhalation challenge after inhalation of furosemide (10 mg/m2 of body) amiloride (0.3 mg/m2 of body), or placebo (0.9% saline solution). Bronchoconstriction was not observed after administration of furosemide and amiloride. Both inhaled furosemide and amiloride exerted a protective effect against AA-induced cough in asthmatic children (p < 0.01 and p < 0.05, respectively), while there was little correlation between the individual protective potency of furosemide and amiloride against AA-induced cough (rs = 0.344, p = 0.255). These results demonstrate that both furosemide and amiloride can attenuate AA-induced cough, although, this protective effect of inhaled diuretics may not necessarily be dependent on Na(+)-K(+)-Cl- cotransporter or Na+ channel in airway epithelial cells.