[Evaluation of multiple prognostic factors in colorectal cancer]

A multivariate stepwise discriminant analysis was performed to evaluate the prognostic value of DI, PI, AgNOR, p21D, CEAD and several clinicopathological features (age, sex, tumor location, histological grading, typing and staging) in 83 patients with colorectal cancer who underwent radical surgery. A fisher's discriminant function was established by using 6 selected items (staging, grading, DI, PI, AgNOR and p21D). It's efficiency, sensitivity and specificity were 91.28%, 87.18%, and 95.45% respectively. Correlative studies on DI, PI, AgNOR and p21D indicated that they are independent factors influencing prognosis. Therefore, in addition to Dukes's classification and histopathological grading of the tumor, these molecular biological factors can be considered as a new clue to evaluation of patients prognosis.